Is CBD Fat Soluble Or Water Soluble?

Cannabidiol is available mainly in the form of oils. Oil and water do not go hand in hand, right? But modern technology has made much of the impossible possible. 

So is CBD water-soluble or fat-soluble? Read on to know!

In this guide, we’ll discuss all the bits you need to know about the solubility of CBD in detail. We will discuss what is water-soluble CBD and the best way to take CBD. 

Moreover, we have also designed a section where you can see details about vitamins. How are vitamins related to CBD? What types of vitamins are there? Are vitamins fat-soluble or water-soluble?

Is CBD Water Soluble Naturally?

We need to look at the compound’s chemistry to answer this question. Cannabidiol is a terpene phenolic compound. This class belongs to the ever-increasing family of organic compounds. By a general rule of thumb, all organic compounds are insoluble in inorganic solvents.

Up close of water.

Therefore, CBD is naturally insoluble in every inorganic solvent like water. Moreover, it readily dissolves in organic solvents like fat and oil. 

We have derived some techniques to incorporate CBD in water. However, it is essential to note that CBD isn’t soluble in water like our regular salt and sugar. We can only incorporate CBD in water via advanced nanotechnology.

So what does Water Soluble CBD mean? See for yourself below.

What Does Water Soluble Mean?

Water-soluble CBD is technically a wrong term. As you know, cannabidiol can not dissolve in water. When referring to water-soluble CBD, we are referring to the compound’s refined form. They are made water-compatible.

Furthermore, we cannot change CBD’s chemical composition. Well, it would not remain CBD if we do so. Water-soluble CBD is just a modified version of regular cannabidiol. Moreover, advanced nanotechnology does this modification.

Now let’s see how exactly an insoluble compound is made compatible with water.

How to Make CBD Water Soluble?

There are three prominent procedures to make Water Soluble CBD. All methods are the wonders of complex science. We will have a look at all of them one by one. 


Nanoemulsion is by far the most advanced procedure to produce water-soluble cannabidiol. The cannabidiol divides into tiny particles in the nanoemulsion(1,000,000 times smaller than a centimeter). 

High energy ultrasound waves create bubbles within the CBD. These bubbles force the CBD droplets to implode. This implosion generates even smaller droplets that can now interact with water.


Liposomes are small bodies with a diameter of 100-5000nm. Being this small, they can easily interact with water. Moreover, lipids are the building blocks of a liposome. 

The plasmalemma of our cells is also lipid in nature. Therefore, a liposome is very useful as it is directly absorbed. Upon reaching the cell, a liposome fuses with the cell membrane. This fusion transfers CBD from our bloodstream to the cells.


Microtech is the precursor of nanotech. The particles are more extensive than nanoparticles. However, they both work on the same principle. 

Nanotech is just more complicated and nuanced than Microtech. Furthermore, unlike nanoemulsions, microemulsions are not self-sufficient. Due to the larger particle size, a microemulsion is less bioavailable.

Moreover, it requires ten times the surfactant as a nanoemulsion. A surfactant is a substance that prevents surface tension and helps in the process. However, it is not suitable for health, so the lesser, the better.

We now know how to make water-soluble CBD. Now, you may have a question in your mind: What is the need to make CBD water-soluble? 

Well, the answer to that is bioavailability.

What Are the Benefits of Water-soluble CBD?

The quality of any supplement depends on its ability to get assimilated by the body cells. The thing is that water-soluble substances are readily taken up by the body. Water Soluble cannabidiol is absorbed efficiently in the blood.

Moreover, a drug is best suited to give the desired outcome in the least amount of time. Also, a drug can only be efficient when absorbed into the bloodstream.

So, smoked CBD gives the best bioavailability. Meaning its vapor form is by far the easiest to absorb. 

Research published in the Phytotherapy Research showed that the bioavailability of water-soluble CBD powder was 4.5 times more than the lipid-soluble CBD powder. 

Besides, when we make Water Soluble CBD from CBD oil, it becomes easier to utilize. Consequently, it gives a brisk and robust effect. We are looking for a fast and complete response when consuming any supplement. That is why we prefer water-soluble cannabidiol instead of oil.

Moving on, let’s look at some of the best water-soluble CBD for sale in the market. We will also add the store links so that you may buy water-soluble CBD from here only.

Best Water Soluble Cannabidiols

There are quite a few brands that claim to sell ‘Best Water Soluble CBD oil.’ However, we did extensive research on the products and the public response to them. 

We have then created this list featuring the Five best products.

  1. Laurelcrest
  2. BulKanna Water Soluble CBD powder
  3. Apricity
  4. Mile High Labs
  5. CBD American Shaman 

We also need to have a look at the dosage of the product. Knowing the dosage is vital as one needs to take the right amount.

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What is the Best Way to Take CBD Oil?

There are several kinds of products available in the market. Furthermore, each product has a different method of administration. However, we are not concerned about the technique. We are worried about the actual value of cannabidiol going into your body.

Nevertheless, a study conducted in 2018 by the National Organization for the Reform of Marijuana Laws (NORML) answered our question. Participants took their dose 90 minutes before a test. 

Participants took doses of 300mg, 600mg, and 150mg. Both the higher and lower doses’ effect was not as convincing as the 300mg dose. Therefore, a 300mg dose of cannabidiol oil is considered optimum.

Furthermore, methods of using water-soluble CBD are reasonably simple. We can spray the product directly onto our palette. 

Moreover, we can always take oral doses in the form of capsules and direct droplets. Also, nanoemulsions are colorless. Being colorless allows it to combine with any sort of food and beverage. 

Surprisingly, water-soluble CBD can also be applied to our skin topically. Unlike oily products, our cells can readily absorb nanoemulsions.

Moreover, we have an even more efficient form of CBD. Namely, the water-soluble CBD isolate.

Water-Soluble CBD or CBD Oil; Which Is Better?

To begin with, both water-soluble and CBD oil have their advantages. Therefore, nothing conclusive can be said about which one is superior to the other. By and large, its’ entirely up to the user’s personal preferences to choose which is better. 

Some people may like water-soluble CBD the most due to various reasons. For instance, water-soluble CBD can help your mental and physical health essentially.

Moreover, since it is available in a powdered form, you can easily mix it in a beverage to enhance the taste. Water-soluble CBD is also handy to use on the go and take with you while traveling.

On the other hand, many CBD users don’t enjoy the taste of a CBD oil tincture. But, it typically has more CBD potency and full-spectrum formulae. Therefore, CBD oil may be more beneficial with added benefits of other cannabinoids and compounds present in a cannabis plant.

Water Soluble CBD Isolate

CBD isolate is the most refined form of cannabidiol. It has the highest percentage of CBD as compared to any product. The purity of CBD is because we follow rigorous extraction regimes. CBD isolate is made so pure that it does not even contain traces of other cannabinoids.

Despite it being so pure, it is still organic. Furthermore, we make it water-compatible using the same nanoemulsion technology.

After a thorough analysis of water-soluble CBD tincture, let’s see its fatty nature. Moreover, we will also have a look at the Fat-Soluble Vitamins.

How to Select a Water-soluble CBD Product?

Due to the increasing demand for CBD products, many CBD brands are now available in the market. But not all of them can be the best.

Here’s what you should look for when buying a water-soluble CBD product.

How Much CBD Does it Contain

Each CBD product must clearly mention per dose CBD serving. It is essential to know how much CBD you are consuming with every dose. This way, you can be sure you’re not overdosing and keep yourself safe.

Moreover, simply “X milligrams of hemp extract” written on the label is not enough. In addition, this does not clarify the percentage or quantity of CBD in the hemp extract.

Third-Party Lab testing

Testing CBD products from an independent lab ensure that they are highly trustworthy and of the best quality. Therefore, always choose a brand that uses US-grown hemp extract and provides third-party lab test reports for each product. 

The test report would further show that the product is free from pesticides or other such chemical compounds.

Artificial Flavors and Sweeteners

Since CBD naturally has a bitter taste, some manufacturers may add sweeteners or flavors to mask it. So, if you plan to take CBD daily, these sweeteners can add high calories to your diet.

Our bodies even take organic sweeteners such as honey, barley malt, and coconut sugar as sugary calories. Hence, you must ensure that it does not contain any artificial flavorings to avoid consuming extra calories.

Is Water-soluble CBD Safe to Use?

Generally, CBD is well-digested by many, according to Mayo Clinic. However, similar to other CBD supplements, water-soluble CBD may also cause some mild issues for you.

The common side effects of CBD may include:

  • Diarrhea
  •  Nausea
  • Dryness of mouth
  • Appetite loss
  • Tiredness
  • Low blood pressure
  • Dizziness

To avoid any mishap, you should always seek a doctor’s advice before consuming CBD. Especially if you are pregnant or using prescriptive medicines, you must take CBD with immense precautions.

Is CBD Fat Soluble?

CBD is naturally an organic compound. Fat is an organic solvent. So, according to introductory chemistry, CBD is soluble in fats and oil.

Furthermore, oil-based CBD products are appropriate, and they get the job done. However, water-soluble products are even better suited for the job.

Also, almost all CBD products come with supplementary vitamins. The reason behind this is that vitamins are essential for our internal development. So manufacturers make our lives easy by adding the vitamins in CBD-based products.

When we get our daily dose of supplements via cannabidiol, we do not need extra accessories.

Now we will have a look at a comprehensive account of vitamins. The report will include fat-soluble vitamins, water-soluble vitamins, and their vitamin table. We will also see why we need vitamins and minerals.

Water-Soluble vs. Fat-Soluble Vitamins

There are several vitamins that our body requires. Vitamins are extremely useful in healing wounds, helping our senses, and many other functions.

Before looking at each vitamin’s functions, let’s see which vitamins are Water Soluble and Fat Soluble.

What Are Fat-Soluble Vitamins?

Fat-soluble vitamins include a wide variety of vitamins. We can easily incorporate them into oils and fats. More importantly, our body stores fat-soluble vitamins in the adipose(fatty) tissues, not in the bloodstream.

So, which Vitamins Are Fat-soluble?

  1. Vitamin A
  2. Vitamin D
  3. Vitamin E
  4. Vitamin K

Besides, it is difficult for our body to excrete fat-soluble vitamins. Therefore, it is vital to keep their concentration within a narrow limit.

What are Water Soluble Vitamins?

There are many water-soluble vitamins. They serve several essential functions in our body. We use vitamins because they support various parts of our body that will never reach completion without assistance.

Which Vitamins are water-soluble?

  1. Vitamin C
  2. Vitamin B Complex

Where Vitamin B complex is a mixture of different vitamins. It includes

  • Vitamin B1(Thiamine)
  • Vitamin B2(Riboflavin)
  • Vitamin B3(Niacin)
  • Vitamin B5(Pantothenic acid)
  • Vitamin B6(Pyridoxine)
  • Vitamin B7(Biotin)
  • Vitamin B9(Folic acid)
  • Vitamin B12(Cobalamin)

Moreover, we also take them to avoid water-soluble vitamin deficiency.

Finally, we will see the functions and sources of fat-soluble vitamins.

Sources and Functions of Vitamins

Before jumping onto our topic, we would like to clear one thing. Despite all of the fat-soluble vitamins being present in CBD, it is not a substitute for naturally acquired vitamins. We can take supplements in the form of water-soluble or fat-soluble CBD, but we should also have foods rich in vitamins.

Vitamin A


We can get a decent amount of vitamin A from our daily diet. Some Vitamin A rich foods are:

  • Dairy products
  • Liver
  • Fish
  • Vegetables like squash, broccoli, and carrots


Vitamin A or Retinol is essential for our eyesight. You must have heard that carrots help improve vision. Well, that is because carrots contain a decent amount of Vitamin A. Moreover, it also helps in bone and teeth formation. Besides, it is integral to both cellular and immune functions.

Deficiency of Vitamin A can cause Night Blindness.

Vitamin D


Vitamin D is one of the most important fat-soluble vitamins. We can get it from many natural sources. Some of them are:

  • Egg yolk
  • Red meat
  • Liver
  • Oily fishes like salmon and mackerel


Vitamin D is crucial for our bones and teeth. It assists in the absorption of calcium, which is an essential mineral for our bones and teeth. Moreover, you must have heard that we can get it from sunlight. 

In reality, we already have a precursor present in our skin. It is converted into an active form when UV rays from the sun fall on it.

Also, Vitamin D helps in the absorption of phosphorus. Its deficiency causes rickets and weak bones.

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Vitamin E


Peanut butter in a jar.

Vitamin E is an essential fat-soluble vitamin. We can get it from many organic sources. Some of them are:

  • Nuts
  • Peanut butter
  • Bell peppers
  • Green vegetables


It is the primary antioxidant present in our body. Its prime function is to build immunity and fight infections. Moreover, it also helps develop our Red Blood Cells in the spleen and bone marrow.

Alternatively, a deficiency of Vitamin E causes a weakened immune response, making our body susceptible to future infections.

Vitamin K


Vitamin K is an essential fat-soluble vitamin. We can get it from many natural sources. Some of them include:

  • Soybean and canola oil
  • Green vegetables
  • Prunes
  • Avocado


The primary function of Vitamin K is to promote blood clotting. However, it also helps in the development of bones.

Low amounts of Vitamin K disrupt blood clotting, and it results in prolonged bleeding.


We hope you now have a clear understanding of the term ‘Water Soluble CBD.’ We are also optimistic that you got the idea of Water Soluble CBD vs. oil. With time, technology is becoming more and more advanced. Who knows if we might make an even more efficient form of CBD.

Until then, water-soluble CBD is the most viable and modern product to make cannabidiol a part of our daily life. We are sure that you will make the most of it.

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